HAS2-AS1 is a novel LH/hCG target gene regulating HAS2 expression and enhancing cumulus cells migration
نویسندگان
چکیده
منابع مشابه
P-221: Impact of Prunus Cerasus on The Expression of HAS2 in Cumulus Cells on Mice
Background: Cherries are an important source of phyto- chemicals, especially anthocyanin. They have many potent biological Properties such as antioxidant activity. Oxidative stress is mainly insert their effect through decreasing of cell proliferation and viability. Infertility problem affect more than 15% of young couples in different societies. Oocyte expansion plays an important role in fert...
متن کاملImpact of Prunus Cerasus on PGR and HAS2 in Cumulus Cells and Fertility Outcome.
PURPOSE Cumulus cells have a critical role in normal oocyte development and fertilization. Prunus cerasus is an anthocyanin rich berry and performs strong antioxidant activity. The present study set to determine if Prunus cerasus can affect expression of HAS2 (hyaluronan synthase 2) and progesterone receptor in Cumulus cells and its consequences outcome of the in vitro fertilization. METHODS ...
متن کاملP-125: The Effect of Eicosapentaenoic Acid (Omega-3) on The Expression of HAS2 in Cumulus Cells on Mice
Background: Omega-3 fatty acids can modify gene and protein expression through altering the function of transcription factors controlling gene expression. Cumulus expansion, is a critical process for normal oocyte development, ovulation, and fertilization. This event needs to the synthesis of hyaluronic acid and its production is controlled by the enzyme hyaluronic acid synthase 2 (HAS2). The a...
متن کاملHas2 is required upstream of Rac1 to govern dorsal migration of lateral cells during zebrafish gastrulation.
The large extracellular polysaccharide Hyaluronan (HA) and its synthesizing enzymes (Has) have been implicated in regulating the migratory potential of metastatic cancer cells. Here, we analyze the roles of zebrafish Has2 in normal development. Antisense morpholino oligonucleotide (MO)-mediated knockdown of zebrafish Has2 leads to the loss of HA, and severe migratory defects during gastrulation...
متن کاملEvaluating The Effect of Melatonin on HAS2 , and PGR Expression, as Well as Cumulus Expansion, and Fertility Potential in Mice
OBJECTIVES Infertility is a worldwide health problem which affects approximately 15% of sexually active couples. One of the factors influencing the fertility is melatonin. Also, protection of oocytes and embryos from oxidative stress inducing chemicals in the culture medium is important. The aim of the present study was to investigate if melatonin could regulate hyaluronan synthase-2 (HAS2) and...
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ژورنال
عنوان ژورنال: Journal of Ovarian Research
سال: 2019
ISSN: 1757-2215
DOI: 10.1186/s13048-019-0495-3